The HIV-1 Env trimer in HD

James B Munro; Walther Mothes

doi:10.1016/j.str.2014.06.004

The HIV-1 Env trimer in HD

Structure. 2014 Jul 8;22(7):935-6. doi: 10.1016/j.str.2014.06.004.

Authors

James B Munro¹, Walther Mothes²

Affiliations

¹ Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
² Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA. Electronic address: [email protected].

Abstract

Understanding the structure of the native HIV-1 envelope spike protein is critical for the development of vaccines and antiviral therapies. In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.

Publication types

Comment

MeSH terms

CD4 Antigens / chemistry*
Humans
Protein Multimerization*
Protein Structure, Quaternary*
env Gene Products, Human Immunodeficiency Virus / chemistry*

Substances

CD4 Antigens
env Gene Products, Human Immunodeficiency Virus

Abstract

Publication types

MeSH terms

Substances

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