Abstract
Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agelas / chemistry*
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Bacillus subtilis / drug effects
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Cryptococcus neoformans / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Hydrocarbons, Brominated / chemistry
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Hydrocarbons, Brominated / isolation & purification*
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Hydrocarbons, Brominated / pharmacology
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KB Cells
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Mice
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Alkaloids
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Hydrocarbons, Brominated
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agelamadin A
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agelamadin B