Cell and tissue engineering for liver disease

Sangeeta N Bhatia; Gregory H Underhill; Kenneth S Zaret; Ira J Fox

doi:10.1126/scitranslmed.3005975

Cell and tissue engineering for liver disease

Sci Transl Med. 2014 Jul 16;6(245):245sr2. doi: 10.1126/scitranslmed.3005975.

Authors

Sangeeta N Bhatia¹, Gregory H Underhill², Kenneth S Zaret³, Ira J Fox⁴

Affiliations

¹ Institute for Medical Engineering & Science at MIT, Department of Electrical Engineering and Computer Science, David H. Koch Institute at MIT, and the Howard Hughes Medical Institute, Cambridge, MA 02139, USA. Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected].
² Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
³ Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴ Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, and McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15224, USA.

Abstract

Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Cell Engineering / methods*
Disease Models, Animal
Humans
Liver / pathology
Liver Diseases / therapy*
Tissue Engineering / methods*
Translational Research, Biomedical

Abstract

Publication types

MeSH terms

Grants and funding