Abstract
A protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates has been developed using a Pd/Q-Phos catalyst. Efficient intermolecular coupling of a variety of ketones with alkenyl bromides was achieved with a slight excess of LiHMDS and temperatures down to 0 °C.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Hydrocarbons, Brominated / chemistry*
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Ketones / chemical synthesis*
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Ketones / chemistry*
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Molecular Structure
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Palladium / chemistry*
Substances
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Alkenes
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Hydrocarbons, Brominated
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Ketones
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Palladium