The immunopathology of cutaneous lupus erythematosus

Rheum Dis Clin North Am. 2014 Aug;40(3):455-74, viii. doi: 10.1016/j.rdc.2014.04.006.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the development of autoantibodies and immunologic attack of different organ systems, including the skin. This review aims to provide an overview of some of the pathogenic processes that may be important in the development of SLE, specifically cutaneous lupus erythematosus, and then illustrates how therapies might be tailored to modify these processes and treat disease.

Keywords: Chemokine; Cutaneous lupus erythematosus; Cytokine; Discoid lupus erythematosus; Interferon-α.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmunity* / drug effects
  • Autoimmunity* / radiation effects
  • Disease Progression
  • Humans
  • Immunity, Innate* / drug effects
  • Immunity, Innate* / radiation effects
  • Immunomodulation*
  • Interferon-alpha / metabolism*
  • Lupus Erythematosus, Cutaneous* / complications
  • Lupus Erythematosus, Cutaneous* / diagnosis
  • Lupus Erythematosus, Cutaneous* / drug therapy
  • Lupus Erythematosus, Cutaneous* / immunology
  • Lupus Erythematosus, Systemic* / drug therapy
  • Lupus Erythematosus, Systemic* / etiology
  • Lupus Erythematosus, Systemic* / physiopathology
  • Risk Factors
  • Ultraviolet Rays / adverse effects

Substances

  • Interferon-alpha