Abstract
Rhodamine-labelled dieckol (1) synthesized through a click reaction was found to be localized in the endoplasmic reticulum (ER) of RAW 264.7 cells. Anti-inflammatory activity of compound was considerably greater than that of dieckol itself.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / metabolism
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Anti-Inflammatory Agents / pharmacology
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Benzofurans / chemistry*
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Cell Line
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Endoplasmic Reticulum / drug effects
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Endoplasmic Reticulum / metabolism
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Interleukin-6 / metabolism
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Lipopolysaccharides / toxicity
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Macrophages / cytology
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Microscopy, Confocal
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Mitogen-Activated Protein Kinases / metabolism
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NF-kappa B / metabolism
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Nitric Oxide / metabolism
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Rhodamines / chemistry*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anti-Inflammatory Agents
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Benzofurans
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Interleukin-6
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Lipopolysaccharides
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NF-kappa B
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Rhodamines
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Tumor Necrosis Factor-alpha
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dieckol
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Nitric Oxide
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Mitogen-Activated Protein Kinases