Abstract
(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinogens
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Catechin / analogs & derivatives*
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Catechin / therapeutic use
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Duodenal Neoplasms / chemically induced
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Duodenal Neoplasms / pathology
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Duodenal Neoplasms / prevention & control*
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Male
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Methylnitronitrosoguanidine / analogs & derivatives*
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Mice
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Mice, Inbred C57BL
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Molecular Structure
Substances
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Carcinogens
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Methylnitronitrosoguanidine
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ENNG
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Catechin
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epigallocatechin gallate