A study of cardiovascular miRNA biomarkers for Kawasaki disease

Pediatr Infect Dis J. 2014 Dec;33(12):1296-9. doi: 10.1097/INF.0000000000000449.

Abstract

We hypothesized that cardiovascular miRNAs might be diagnostic biomarkers for Kawasaki disease (KD). We identified dysregulated miRNAs in KD coronary arteries, and tested sera from KD patients and febrile controls for cardiovascular miRNAs using 2 methods. We did not identify cardiovascular miRNAs diagnostic for KD; our results may help guide future studies of potential miRNA biomarkers for KD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / analysis*
  • Biomarkers / blood*
  • Child
  • Coronary Vessels / pathology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • MicroRNAs / analysis*
  • MicroRNAs / blood*
  • Mucocutaneous Lymph Node Syndrome / genetics*
  • Mucocutaneous Lymph Node Syndrome / pathology*

Substances

  • Biomarkers
  • MicroRNAs