Abstract
Tissue factor is the cellular receptor and cofactor for plasma factor VIIa which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blotting, Northern
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Cells, Cultured
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Cycloheximide / pharmacology
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DNA / genetics
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DNA Probes
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Gene Expression Regulation / drug effects*
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Humans
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Interferon-gamma / pharmacology
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Interleukin-1 / biosynthesis
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Interleukin-3 / pharmacology
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Lipopolysaccharides / pharmacology*
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Monocytes / metabolism*
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RNA, Messenger / genetics
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Recombinant Proteins
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Thromboplastin / genetics*
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / genetics
Substances
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DNA Probes
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Interleukin-1
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Interleukin-3
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Lipopolysaccharides
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RNA, Messenger
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma
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DNA
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Thromboplastin
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Cycloheximide