mtDNA sequence, phylogeny and evolution of laboratory mice

Junfeng Zheng; Yan Chen; Fengyuan Deng; Renliang Huang; Frank Petersen; Saleh Ibrahim; Xinhua Yu

doi:10.1016/j.mito.2014.07.006

mtDNA sequence, phylogeny and evolution of laboratory mice

Mitochondrion. 2014 Jul:17:126-31. doi: 10.1016/j.mito.2014.07.006. Epub 2014 Jul 16.

Authors

Junfeng Zheng¹, Yan Chen¹, Fengyuan Deng¹, Renliang Huang¹, Frank Petersen², Saleh Ibrahim³, Xinhua Yu⁴

Affiliations

¹ The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China.
² Priority Area Asthma and Allergy, Research Center Borstel, 23845 Borstel, Germany, Airway Research Center North (ARCN), UGMLC, Member of the German Center for Lung Research (DZL).
³ Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany.
⁴ The Medical College of Xiamen University, Xiamen University, 361005 Xiamen, China; Priority Area Asthma and Allergy, Research Center Borstel, 23845 Borstel, Germany, Airway Research Center North (ARCN), UGMLC, Member of the German Center for Lung Research (DZL). Electronic address: [email protected].

PMID: 25038446
DOI: 10.1016/j.mito.2014.07.006

Abstract

Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100years in the laboratory mice are under a relaxed purifying selection.

Keywords: Inbred strains; Outbred stock; Phylogenetic history; Relaxed purifying selection; mtDNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA, Mitochondrial / genetics*
Evolution, Molecular*
Female
Male
Mice
Phylogeny*
Polymorphism, Genetic
Selection, Genetic

Substances

DNA, Mitochondrial