Quantitative fluorometric assay for the measurement of endo-1,4-β-glucanase

Carbohydr Res. 2014 Aug 18:395:47-51. doi: 10.1016/j.carres.2014.05.002. Epub 2014 May 15.

Abstract

There is a growing demand for research tools to aid the scientific community in the search for improved cellulase enzymes for the biofuel industry. In this work, we describe a novel fluorometric assay for cellulase (endo-1,4-β-glucanase) which is based on the use of 4,6-O-benzylidene-4-methylumbelliferyl-β-cellotrioside (BzMUG3) in the presence of an ancillary β-glucosidase. This assay can be used quantitatively over a reasonable linear range, or qualitatively as a solution screening tool which may find extensive use in the area of metagenomics.

Keywords: 4-Methylumbelliferone; Assay procedure; Cellulase; Fluorometric; Metagenomics; endo-1,4-β-Glucanase.

MeSH terms

  • Benzylidene Compounds / chemistry
  • Biological Assay*
  • Cellulase / analysis*
  • Cellulase / chemistry
  • Cellulose / chemistry
  • Enzyme Assays
  • Fluorescent Dyes / chemistry
  • Fluorometry / methods*
  • Fungal Proteins / analysis*
  • Fungal Proteins / chemistry
  • Hymecromone / chemistry*
  • Kinetics
  • Trichoderma / chemistry
  • Trichoderma / enzymology
  • beta-Glucosidase / chemistry

Substances

  • Benzylidene Compounds
  • Fluorescent Dyes
  • Fungal Proteins
  • Hymecromone
  • Cellulose
  • beta-Glucosidase
  • Cellulase