1 aMolecular Psychiatry Laboratory, Division of Psychiatry, UCL, London bUCL Institute for Liver & Digestive Health, University College London cNational Addiction Centre and Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London dGatehouse Alcohol Clinic and Max Glatt Unit, Central and North West London NHS Foundation Trust, St Bernards Hospital, Middlesex eOxford Health NHS Foundation Trust, Warneford Hospital, Headington, Oxford fBexley Substance Misuse Services, South London & Maudsley NHS Trust, Erith Health Centre, Kent gRoyal Alexandra Hospital hCathcart Centre iGartnavel Royal Hospital, NHS Greater Glasgow & Clyde, Glasgow jQueens Medical Centre, Nottingham kNewcastle and North Tyneside Addictions Service, Plummer Court, Newcastle upon Tyne, UK.