The use of spirocyclic scaffolds in drug discovery

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3673-82. doi: 10.1016/j.bmcl.2014.06.081. Epub 2014 Jul 5.

Abstract

Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery.

Keywords: Drug discovery; Scaffold; Spirocyclic.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical
  • Drug Discovery*
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds / pharmacology*
  • Humans
  • Molecular Structure
  • Spiro Compounds / chemical synthesis
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*

Substances

  • Heterocyclic Compounds
  • Spiro Compounds