PET/CT with (124)I-cG250: great potential and some open questions

AJR Am J Roentgenol. 2014 Aug;203(2):261-2. doi: 10.2214/AJR.14.12490.

Abstract

Objective: A novel PET radiotracer, (124)I-cG250, is currently under clinical investigation to distinguish clear cell renal cell carcinoma from other benign and malignant renal masses. In this article, we will make suggestions on the data needed to maximize the use of this radiotracer.

Conclusion: Although the published data are promising, further data are needed to assess the potential usefulness of this agent when dealing with indeterminate renal masses.

Keywords: 124I-cG250 PET/CT; clear cell renal cell carcinoma; indeterminate renal masses.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal*
  • Carbonic Anhydrases / metabolism
  • Carcinoma, Renal Cell / diagnostic imaging*
  • Carcinoma, Renal Cell / metabolism
  • Carcinoma, Renal Cell / pathology
  • Humans
  • Iodine Radioisotopes*
  • Kidney Neoplasms / diagnostic imaging*
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / pathology
  • Multimodal Imaging*
  • Neoplasm Grading
  • Positron-Emission Tomography / methods*
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*

Substances

  • Antibodies, Monoclonal
  • G250 monoclonal antibody
  • Iodine Radioisotopes
  • Carbonic Anhydrases