Daptomycin susceptibility of 833 strains of Gram-positive cocci from a university hospital in Japan (2009-2011)

Diagn Microbiol Infect Dis. 2014 Oct;80(2):151-3. doi: 10.1016/j.diagmicrobio.2014.06.011. Epub 2014 Jun 21.

Abstract

The aim of this study was to confirm the daptomycin (DAP) susceptibility of bacteria isolated before the launch of DAP in Japan. DAP showed good activity against all 833 isolates (MIC90 = 0.25-0.5 mg/L for staphylococci, 0.5-4 mg/L for enterococci, and 0.25-0.5 mg/L for streptococci). This is the first report of the in vitro activity of DAP against Gram-positive cocci, including methicillin-resistant Staphylococcus aureus and enterococci, isolated in Japan.

Keywords: Antibiotic susceptibility; Daptomycin; Gram-positive cocci; MRSA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Daptomycin / pharmacology*
  • Gram-Positive Bacterial Infections / microbiology
  • Gram-Positive Cocci / drug effects*
  • Gram-Positive Cocci / isolation & purification
  • Hospitals, University
  • Humans
  • Japan
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Daptomycin