Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids

J Org Chem. 2014 Aug 15;79(16):7633-48. doi: 10.1021/jo5014492. Epub 2014 Aug 1.

Abstract

Allylic trichloroacetimidates bearing a 2-vinyl or 2-allylaryl group have been designed as substrates for a one-pot, two-step multi-bond-forming process leading to the general preparation of aminoindenes and amino-substituted 1,4-dihydronaphthalenes. The synthetic utility of the privileged structures formed from this one-pot process was demonstrated with the total synthesis of four oxybenzo[c]phenanthridine alkaloids, oxychelerythrine, oxysanguinarine, oxynitidine, and oxyavicine. An intramolecular biaryl Heck coupling reaction, catalyzed using the Hermann-Beller palladacycle was used to effect the key step during the synthesis of the natural products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemistry
  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Biological Products / chemical synthesis*
  • Biological Products / chemistry*
  • Cyclization
  • Indenes / chemical synthesis*
  • Indenes / chemistry*
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Phenanthridines / chemical synthesis*
  • Phenanthridines / chemistry*
  • Stereoisomerism
  • Vinyl Compounds / chemistry

Substances

  • Acetamides
  • Alkaloids
  • Biological Products
  • Indenes
  • Naphthalenes
  • Phenanthridines
  • Vinyl Compounds
  • oxyavicine
  • oxysanguinarine
  • oxynitidine