Association between GUC2C and ADHD: evidence from both categorical and quantitative traits

Psychiatry Res. 2014 Dec 15;220(1-2):708-10. doi: 10.1016/j.psychres.2014.06.051. Epub 2014 Jul 9.

Abstract

Guanylyl cyclase-C knock-out mice exhibit hyperactivity and attention deficits. We investigated seven single nucleotide polymorphisms (SNPs) of Guanylate cyclase 2C gene (GUC2C) in 381 ADHD trios and 382 healthy controls. Transmission disequilibrium tests (TDT), case-control studies and quantitative analyses indicated association between GUC2C with ADHD and its core symptoms.

Keywords: Association; Attention-deficit/hyperactivity disorder; GUC2C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Attention Deficit Disorder with Hyperactivity / genetics*
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Linkage Disequilibrium
  • Mice
  • Mice, Knockout
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Quantitative Trait, Heritable*
  • Receptors, Enterotoxin
  • Receptors, Guanylate Cyclase-Coupled / genetics*
  • Receptors, Peptide / genetics*

Substances

  • Receptors, Peptide
  • GUCY2C protein, human
  • Gucy2c protein, mouse
  • Receptors, Enterotoxin
  • Receptors, Guanylate Cyclase-Coupled