Triterpenoids and α-glucosidase inhibitory constituents from Salacia hainanensis

Fitoterapia. 2014 Oct:98:143-8. doi: 10.1016/j.fitote.2014.07.016. Epub 2014 Jul 27.

Abstract

Thirteen triterpenoids (1-13), including two new lupane triterpenoids, salacinins A and B (1 and 2), as well as one new friedelane triterpenoid, salacinin C (3), were isolated from the roots and stems of Salacia hainanensis. The structures of new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, and MS experiments. Compound 1 possesses rare 2,3-seco-lupane skeleton. Compounds 4, 6 and 7 showed inhibitory effects on α-glucosidase in vitro.

Keywords: Friedelane; Lupine; Salacia hainanensis; α-Glucosidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycoside Hydrolase Inhibitors / chemistry*
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Molecular Structure
  • Plant Roots / chemistry
  • Plant Stems / chemistry
  • Salacia / chemistry*
  • Salacia / metabolism*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • alpha-Glucosidases

Substances

  • Glycoside Hydrolase Inhibitors
  • Triterpenes
  • friedelane
  • salacinin A
  • salacinin B
  • lupane
  • alpha-Glucosidases