Abstract
Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding that was extended to peripheral blood samples from other cohorts of prospectively followed individuals.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anxiety / genetics
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Cadaver
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Chromosomal Proteins, Non-Histone / genetics*
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DNA Methylation
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Epigenesis, Genetic*
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Female
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Gene Expression Regulation
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Genetic Markers
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Genetic Variation
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Genome-Wide Association Study
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Humans
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Hydrocortisone / metabolism
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Living Donors
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Male
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Middle Aged
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Neuroglia / metabolism*
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Neurons / metabolism*
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Predictive Value of Tests
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Prefrontal Cortex / metabolism*
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Saliva / metabolism
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Sequence Analysis, DNA
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Stress, Psychological / genetics*
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Suicidal Ideation
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Suicide*
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Suicide, Attempted
Substances
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Chromosomal Proteins, Non-Histone
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Genetic Markers
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SKA2 protein, human
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Hydrocortisone