Abstract
An l-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric l-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / chemistry
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Animals
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Antigen-Presenting Cells
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Antigens / chemistry
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DNA / chemistry
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Enzyme-Linked Immunosorbent Assay
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Epitopes / chemistry
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Fluorescent Dyes / chemistry
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Glycopeptides / chemistry
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Humans
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Hydrogels / chemistry
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Hydrogen-Ion Concentration
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Immune System
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Immunoglobulin G / chemistry
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Immunoglobulin M / chemistry
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Immunosuppressive Agents / chemistry*
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Liposomes / chemistry
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Mice
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Micelles
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Microscopy, Electron, Transmission
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Nanoparticles / chemistry*
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Nanotechnology / methods
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Peptides / chemistry
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Rhamnose / chemistry*
Substances
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Adjuvants, Immunologic
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Antigens
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Epitopes
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Fluorescent Dyes
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Glycopeptides
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Hydrogels
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Immunoglobulin G
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Immunoglobulin M
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Immunosuppressive Agents
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Liposomes
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Micelles
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Peptides
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DNA
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Rhamnose