Abstract
Two new triterpenesaponins, ilexsaponins G and H (1 and 2), together with six known triterpenesaponins (3-8), were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Those compounds showed inhibitory activities against two human colorectal cancer cell lines HCT 116 and HT-29.
Keywords:
Ilex pubescens; cytotoxicity; ilexsaponin G; ilexsaponin H; triterpenesaponins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Colorectal Neoplasms / drug therapy
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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HCT116 Cells
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HT29 Cells
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Humans
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Ilex / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Paclitaxel / pharmacology
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Plant Roots / chemistry
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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ilexsaponin G
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ilexsaponin H
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Paclitaxel