Serotonin toxicity in a CYP2D6 poor metabolizer, initially diagnosed as a drug-resistant major depression

Am J Psychiatry. 2014 Aug;171(8):890. doi: 10.1176/appi.ajp.2014.13101377.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Cyclohexanols / administration & dosage
  • Cyclohexanols / adverse effects
  • Cyclohexanols / pharmacokinetics
  • Cytochrome P-450 CYP2D6 / genetics
  • Delayed-Action Preparations
  • Depressive Disorder, Treatment-Resistant / diagnosis*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / pharmacokinetics
  • Serotonin Syndrome / chemically induced*
  • Serotonin Syndrome / genetics*
  • Venlafaxine Hydrochloride

Substances

  • Cyclohexanols
  • Delayed-Action Preparations
  • Serotonin Uptake Inhibitors
  • Venlafaxine Hydrochloride
  • Cytochrome P-450 CYP2D6