Phagocytic multiple myeloma with disseminated intravascular coagulation

Acta Haematol. 1989;82(2):91-4. doi: 10.1159/000205290.

Abstract

We describe an atypical case of IgG lambda multiple myeloma in a 28-year-old patient. He developed multiple cutaneous plasmacytomas, and the terminal event, leukemic conversion by phagocytic plasma cells and disseminated intravascular coagulation. Secretion of monoclonal immunoglobulin (IgG lambda) from myeloma cells was demonstrated by plaque-forming cell assay. Electron microscopy showed myeloma cells with well-developed rough endoplasmic reticulum and erythroid cells or platelets in intracytoplasmic vacuoles.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Neoplasm / analysis
  • Disseminated Intravascular Coagulation / etiology*
  • Humans
  • Leukemia, Plasma Cell / pathology
  • Male
  • Microscopy, Electron
  • Multiple Myeloma / immunology
  • Multiple Myeloma / pathology*
  • Skin Neoplasms / pathology

Substances

  • Antigens, Neoplasm