Congenital multifocal increase of Purkinje fibres in a calf with cardiac conduction delay

M Sakurai; N Kuninaga; T Takeuchi; T Tsuka; T Morita

doi:10.1016/j.jcpa.2014.06.002

Congenital multifocal increase of Purkinje fibres in a calf with cardiac conduction delay

J Comp Pathol. 2014 Aug-Oct;151(2-3):234-7. doi: 10.1016/j.jcpa.2014.06.002. Epub 2014 Jul 30.

Authors

M Sakurai¹, N Kuninaga¹, T Takeuchi², T Tsuka³, T Morita⁴

Affiliations

¹ Department of Veterinary Pathology, Tottori University, Tottori, Japan.
² Department of Veterinary Laboratory Medicine, Tottori University, Tottori, Japan.
³ Department of Veterinary Diagnostic Imaging, Tottori University, Tottori, Japan.
⁴ Department of Veterinary Pathology, Tottori University, Tottori, Japan. Electronic address: [email protected].

PMID: 25084712
DOI: 10.1016/j.jcpa.2014.06.002

Abstract

A female 4-month-old Holstein-Friesian calf was presented in heart failure. Microscopical examination of samples of the cardiac wall taken at necropsy examination revealed numerous aggregates of Purkinje fibres, particularly in the perivascular areas. Some Purkinje fibres were stained strongly with phosphotungstic acid haematoxylin and immunohistochemically were shown to express alpha smooth muscle actin, indicating an embryonic-like Purkinje fibre phenotype. A diagnosis of congenital multifocal increase of Purkinje fibres was made. The histological features of this case resemble multifocal cardiac Purkinje cell tumour of the heart in man.

Keywords: Purkinje fibre; calf; congenital anomaly; heart.

Publication types

Case Reports

MeSH terms

Animals
Arrhythmias, Cardiac / congenital
Arrhythmias, Cardiac / pathology
Arrhythmias, Cardiac / veterinary*
Brugada Syndrome
Cardiac Conduction System Disease
Cattle
Cattle Diseases / congenital*
Cattle Diseases / pathology*
Female
Heart Conduction System / abnormalities*
Heart Conduction System / pathology
Purkinje Fibers / pathology*