Longer incubation times for yeast fungemia: importance for presumptive treatment

André Paugam; Thierry Ancelle; Olivier Lortholary; Stéphane Bretagne; French Mycosis Study Group

doi:10.1016/j.diagmicrobio.2014.05.013

Longer incubation times for yeast fungemia: importance for presumptive treatment

Diagn Microbiol Infect Dis. 2014 Oct;80(2):119-21. doi: 10.1016/j.diagmicrobio.2014.05.013. Epub 2014 May 20.

Authors

André Paugam¹, Thierry Ancelle², Olivier Lortholary³, Stéphane Bretagne⁴; French Mycosis Study Group

Affiliations

¹ Université Paris Descartes-Paris 5, Service de Parasitologie-Mycologie, Hôpital Cochin, APHP, Paris, France. Electronic address: [email protected].
² Université Paris Descartes-Paris 5, Service de Parasitologie-Mycologie, Hôpital Cochin, APHP, Paris, France.
³ Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France; CNRS URA3012, Paris, France; Université Paris Descartes-Paris 5, Service de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants malades, APHP, Centre d'Infectiologie Necker Pasteur, IHU Imagine, Paris, France.
⁴ Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France; Université Paris Diderot- Paris 7, Service de Parasitologie-Mycologie, Hôpital Saint-Louis, APHP, Créteil, France.

PMID: 25085022
DOI: 10.1016/j.diagmicrobio.2014.05.013

Abstract

Isolation rates of Candida glabrata at ≤2 days were 8.9% and 34.8% at >2 days; for Cryptococcus neoformans, they were 0.9% and 8.6%, respectively (1741 fungemia analyzed). An incubation time >2 days supports candins as presumptive treatment for C. glabrata, keeping in mind the risk of Cryptococcus fungemia.

Keywords: automated blood cultures; candidemia; incubation time.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / therapeutic use*
Candida glabrata / isolation & purification*
Cryptococcus neoformans / isolation & purification*
Fungemia / diagnosis*
Fungemia / drug therapy*
Humans
Time Factors

Substances

Antifungal Agents