Preparation and self-folding of amphiphilic DNA origami

Chao Zhou; Dianming Wang; Yuanchen Dong; Ling Xin; Yawei Sun; Zhongqiang Yang; Dongsheng Liu

doi:10.1002/smll.201401576

Preparation and self-folding of amphiphilic DNA origami

Small. 2015 Mar;11(9-10):1161-4. doi: 10.1002/smll.201401576. Epub 2014 Aug 1.

Authors

Chao Zhou¹, Dianming Wang, Yuanchen Dong, Ling Xin, Yawei Sun, Zhongqiang Yang, Dongsheng Liu

Affiliation

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

PMID: 25087844
DOI: 10.1002/smll.201401576

Abstract

Amphiphilic DNA origami is prepared by dressing multiple hydrophobic molecules on a rectangular single layer DNA origami, which is then folded or coupled in sandwich-like structures with two outer DNA origami layer and one inner hydrophobic molecules layer. The preference to form different kinds of structures could be tailored by rational design of DNA origami.

Keywords: DNA origami; DNA structures; hydrophobic effect; self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Materials Testing
Microscopy, Atomic Force
Nanostructures / chemistry*
Nanotechnology
Nucleic Acid Conformation*
Surface Properties
Temperature

Substances

DNA