Abstract
The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Arachidonic Acid
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Arachidonic Acids / pharmacology
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Blood Coagulation / drug effects
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Hydroxyeicosatetraenoic Acids / administration & dosage
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Hydroxyeicosatetraenoic Acids / pharmacology*
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Lipoxins*
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Male
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Platelet Aggregation / drug effects*
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Rats
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Rats, Inbred Strains
Substances
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Arachidonic Acids
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Hydroxyeicosatetraenoic Acids
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Lipoxins
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Arachidonic Acid
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5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid
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lipoxin B4