Abstract
Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own α-subunit in hypoxic cancer cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line
-
Epigenesis, Genetic*
-
Gene Expression Regulation*
-
Humans
-
Hypoxia / genetics
-
Hypoxia / metabolism
-
Hypoxia-Inducible Factor 1 / metabolism*
-
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
-
Protein Binding
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
Transcriptional Activation*
Substances
-
Hypoxia-Inducible Factor 1
-
Hypoxia-Inducible Factor 1, alpha Subunit
-
RNA, Messenger