Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy

J Clin Oncol. 2016 Apr 1;34(10):e87-9. doi: 10.1200/JCO.2013.51.1766. Epub 2014 Aug 4.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Astrocytoma / drug therapy*
  • Astrocytoma / genetics*
  • Astrocytoma / pathology
  • Astrocytoma / therapy
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy
  • Drug Administration Schedule
  • Drug Eruptions / etiology
  • Frontal Lobe / pathology
  • Glutamic Acid
  • Humans
  • Indoles / administration & dosage
  • Indoles / adverse effects
  • Indoles / therapeutic use*
  • Magnetic Resonance Imaging
  • Male
  • Mutation*
  • Neoplasm Staging
  • Proto-Oncogene Proteins B-raf / genetics*
  • Sulfonamides / administration & dosage
  • Sulfonamides / adverse effects
  • Sulfonamides / therapeutic use*
  • Temporal Lobe / pathology
  • Treatment Outcome
  • Valine
  • Vemurafenib
  • Xanthomatosis / drug therapy*
  • Xanthomatosis / genetics*
  • Xanthomatosis / pathology
  • Xanthomatosis / therapy

Substances

  • Antineoplastic Agents
  • Indoles
  • Sulfonamides
  • Vemurafenib
  • Glutamic Acid
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Valine

Associated data

  • ClinicalTrials.gov/NCT02034110