Significant decreases of interleukin-1α gene expression after application of the serotonin receptor antagonist ondansetron are found to correlate with antiproliferative properties in the acute lymphoblastic leukemia cell line REH

Leuk Lymphoma. 2015 Apr;56(4):1157-9. doi: 10.3109/10428194.2014.951850. Epub 2014 Sep 8.

Authors

Javier Prada¹, Huayan Long

Affiliation

¹ Biomedical Research Center, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Humboldt University of Berlin , Berlin , Germany.

PMID: 25098424
DOI: 10.3109/10428194.2014.951850

No abstract available

Publication types

Letter

MeSH terms

Cell Line, Tumor
Cell Proliferation / drug effects*
Cell Proliferation / genetics
Dose-Response Relationship, Drug
Gene Expression Regulation, Leukemic / drug effects*
Humans
In Situ Hybridization
Interleukin-1alpha / genetics*
Ondansetron / pharmacology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Serotonin / pharmacology
Serotonin Antagonists / pharmacology

Substances

Interleukin-1alpha
Serotonin Antagonists
Serotonin
Ondansetron