A local circadian clock calls time on lung inflammation

Nat Med. 2014 Aug;20(8):809-11. doi: 10.1038/nm.3649.

Abstract

Inflammatory diseases typically display circadian variation in symptom severity. A new study in mice shows how a pulmonary epithelial cell clock controls neutrophil recruitment to the lungs and provides insight into interactions between local and systemic circadian clocks.

Publication types

  • Comment

MeSH terms

  • ARNTL Transcription Factors / immunology*
  • Animals
  • Chemokine CXCL5 / immunology*
  • Circadian Clocks / immunology*
  • Glucocorticoids / pharmacology*
  • Humans
  • Pneumonia, Pneumococcal / immunology*
  • Streptococcus pneumoniae*

Substances

  • ARNTL Transcription Factors
  • Bmal1 protein, mouse
  • Chemokine CXCL5
  • Cxcl5 protein, mouse
  • Glucocorticoids