The tailless root of glioma: cancer stem cells

Qi Xie; William A Flavahan; Shideng Bao; Jeremy Rich

doi:10.1016/j.stem.2014.07.004

The tailless root of glioma: cancer stem cells

Cell Stem Cell. 2014 Aug 7;15(2):114-6. doi: 10.1016/j.stem.2014.07.004.

Authors

Qi Xie¹, William A Flavahan¹, Shideng Bao¹, Jeremy Rich²

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA.
² Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA. Electronic address: [email protected].

Abstract

In this issue of Cell Stem Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functional cellular hierarchy defined by expression of the nuclear orphan receptor Tlx. Targeting cancer stem cells through genetic deletion of TLX promotes cancer stem cell death and differentiation and extends survival.

Publication types

Comment

MeSH terms

Animals
Brain Neoplasms / pathology*
Glioma / pathology*
Humans
Neoplastic Stem Cells / pathology*

Abstract

Publication types

MeSH terms

Grants and funding