Anesthesia-induced epilepsy: causes and treatment

Expert Rev Neurother. 2014 Sep;14(9):1099-113. doi: 10.1586/14737175.2014.948851. Epub 2014 Aug 13.

Abstract

Epilepsy is a type of chronic brain disease that results from an abnormally high synchronization of neuronal discharge. The typical clinical features of epilepsy are paroxysms and transient and stereotyped brain dysfunction. Many cases of epileptic seizures occurring during anesthesia have been reportedx. Recently, risk assessment of epileptic seizures during surgery and anesthesia has gained increasing attention. In this review, we systematically summarize the influence of anesthesia on epileptic seizures; the types, durations and frequencies of seizures related to anesthesia; and the epidemiology, prevention, treatment and prognosis of epilepsy. We also explore the possible mechanism of epilepsy and provide guidance for anesthesia during surgeries.

Keywords: anesthesia; anesthetic; epilepsy; epileptic seizure; mechanism.

Publication types

  • Review

MeSH terms

  • Anesthesia / adverse effects*
  • Animals
  • Brain / metabolism
  • Epilepsy / chemically induced*
  • Epilepsy / epidemiology
  • Epilepsy / pathology
  • Epilepsy / therapy*
  • Humans