Abstract
c-di-AMP is an important bacterial second messenger found in Gram-positive and mycobacteria. c-di-AMP regulates myriads of processes in bacteria as well as immune response in higher organisms so interest in small molecules that would attenuate the activity of c-di-AMP metabolism enzymes is high. Herein, we report the first small molecule inhibitor of a c-di-AMP synthase, DisA, using a coralyne-based assay.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Berberine Alkaloids / analysis
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Berberine Alkaloids / chemistry*
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Dinucleoside Phosphates / biosynthesis*
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Dose-Response Relationship, Drug
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Enzyme Assays*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Molecular Structure
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Nucleotidyltransferases / antagonists & inhibitors*
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Nucleotidyltransferases / metabolism
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Phenols / chemical synthesis
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Phenols / chemistry
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Phenols / pharmacology*
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Small Molecule Libraries / chemical synthesis
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology*
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Structure-Activity Relationship
Substances
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Berberine Alkaloids
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Dinucleoside Phosphates
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Enzyme Inhibitors
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Phenols
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Small Molecule Libraries
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cyclic diadenosine phosphate
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coralyne
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Nucleotidyltransferases
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4-bromophenol