Abstract
Neisseria meningitidis group B (MenB) strains isolated from 1976 to 1987 in Finland in 339 patients with invasive infection were sero/subtyped by whole cell enzyme immunoassay using monoclonal antibodies to class 1 and 2/3 outer membrane proteins. 66.7% of the strains could be serotyped (class 2/3) and 70.2% subtyped (class 1). No single phenotype was clearly predominant. The most common serotypes were 4 (18.6%) and 14 (17.4%) and the most common subtypes P1.16 (20.1%) and P1.2 (12.1%). The Norwegian phenotype B:15:P1.16 was seen only rarely (a total of 18 strains). Strains from Northern Finland did not differ from those from Southern Finland: no single phenotype caused the slight increase seen in the incidence of MenB infections in the end of 1970s in the North.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal
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Bacterial Outer Membrane Proteins / analysis
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Bacterial Outer Membrane Proteins / immunology
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Bacterial Typing Techniques
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Cerebrospinal Fluid / microbiology
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Finland / epidemiology
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Humans
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Immunoenzyme Techniques
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Meningitis, Meningococcal / epidemiology
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Meningitis, Meningococcal / microbiology*
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Meningitis, Meningococcal / mortality
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Meningococcal Infections / epidemiology
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Meningococcal Infections / microbiology*
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Meningococcal Infections / mortality
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Nasopharynx / microbiology
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Neisseria meningitidis / classification*
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Neisseria meningitidis / immunology
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Neisseria meningitidis / isolation & purification
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Phenotype
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Serotyping
Substances
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Antibodies, Monoclonal
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Bacterial Outer Membrane Proteins