Abstract
A new phenyl glycoside, 2-(sophorosyl)-1-(4-hydroxyphenyl)ethanone (9), was isolated from the ethanolic extract of the aerial parts of Equisetum hyemale L., together with eight known compounds (1-8). The structures of these compounds were elucidated using a combination of spectroscopic analyses and chemical method. Of these nine compounds, 4 and 7 showed hepatoprotective effects towards tacrine-induced cytotoxicity in Hep 3B cells with EC50 values of 42.7 ± 1.5 and 132.6 ± 2.8 μM, respectively.
Keywords:
5-hydroymethylfurfural; Equisetum hyemale L; hepatoprotective effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chemical and Drug Induced Liver Injury / drug therapy
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Equisetum / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Tacrine / pharmacology
Substances
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2-(sophorosyl)-1-(4-hydroxyphenyl)ethanone
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glycosides
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Phenols
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Plant Extracts
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Tacrine