Abstract
Helminth-induced immunomodulation is thought to influence the outcome of secondary infections. Osborne et al. (2014) and Reese et al. (2014) demonstrate that helminth infection impacts viral infections by tilting the immune system toward Th2/M2 immune regulatory responses that dampen Th1/M1 antiviral responses as well as promote reactivation of latent herpesviruses.
Copyright © 2014 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Animals
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Caliciviridae Infections / immunology*
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Coinfection / immunology*
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Gammaherpesvirinae / physiology*
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Gastroenteritis / immunology*
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Herpesvirus 8, Human / physiology*
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Humans
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Immunomodulation*
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Interferon-gamma / immunology*
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Interleukin-4 / metabolism*
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Lectins / immunology*
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Microbiota / immunology*
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Norovirus / immunology*
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STAT6 Transcription Factor / metabolism*
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Schistosoma mansoni / immunology*
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Schistosomiasis mansoni / immunology*
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Trichinella / immunology*
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Trichinellosis / immunology*
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Virus Activation / physiology*
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beta-N-Acetylhexosaminidases / immunology*
Substances
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Lectins
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STAT6 Transcription Factor
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Interleukin-4
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Interferon-gamma
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beta-N-Acetylhexosaminidases