How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Cell Host Microbe. 2014 Aug 13;16(2):150-152. doi: 10.1016/j.chom.2014.07.013.

Abstract

Early in viral infection, the STAT1 transcription factor is rapidly transported into the nucleus using a nonconventional import mechanism to establish an antiviral state. In this issue, Xu et al. (2014) show how the Ebola virus VP24 protein precisely blocks specialized STAT1 import while leaving other cellular import processes intact.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Ebolavirus / physiology*
  • Humans
  • STAT1 Transcription Factor / metabolism*
  • Viral Proteins / chemistry*
  • alpha Karyopherins / chemistry*

Substances

  • KPNA5 protein, human
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • VP24 protein, Ebola virus
  • Viral Proteins
  • alpha Karyopherins