Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy

Adv Mater. 2014 Oct 8;26(37):6401-8. doi: 10.1002/adma.201400914. Epub 2014 Aug 14.

Abstract

Multimodal imaging-guided photothermal therapy (PTT), for the therapy of cancer, based on a ferritin (FRT) nanocage loaded with the near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles of DFRT (in imaging and PTT) are successfully balanced by using two different excitation wavelengths: 550 nm for high quantum-yield fluorescence imaging on the one hand and 808 nm for photoacoustic imaging and PTT with high photothermal conversion efficiency on the other.

Keywords: ferritin; fluorescence imaging; photoacoustic imaging; photothermal therapy; theranostics.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Ferritins / chemistry*
  • Fluorescent Dyes / chemistry*
  • Indocyanine Green / chemistry
  • Lasers
  • Mice
  • Microscopy, Atomic Force
  • Microscopy, Fluorescence
  • Nanostructures / chemistry*
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Oligopeptides / chemistry
  • Particle Size
  • Photochemotherapy
  • Photosensitizing Agents / pharmacokinetics
  • Photosensitizing Agents / therapeutic use
  • Tissue Distribution
  • Transplantation, Homologous
  • Ultrasonography

Substances

  • Fluorescent Dyes
  • Oligopeptides
  • Photosensitizing Agents
  • arginyl-glycyl-aspartic acid
  • Ferritins
  • Indocyanine Green