Physical activity modifies the associations between genetic variants and blood pressure in European adolescents

Augusto César Ferreira de Moraes; Juan Miguel Fernández-Alvira; Heráclito Barbosa Carvalho; Aline Meirhaeghe; Jean Dallongeville; Anthony Kafatos; Ascensión Marcos; Dénes Molnar; Yannis Manios; Jonatan R Ruiz; Idoia Labayen; Kurt Widhalm; Christina Breidenassel; Marcela Gonzalez-Gróss; Luis A Moreno

doi:10.1016/j.jpeds.2014.07.007

Physical activity modifies the associations between genetic variants and blood pressure in European adolescents

J Pediatr. 2014 Nov;165(5):1046-9.e1-2. doi: 10.1016/j.jpeds.2014.07.007. Epub 2014 Aug 14.

Authors

Augusto César Ferreira de Moraes¹, Juan Miguel Fernández-Alvira², Heráclito Barbosa Carvalho³, Aline Meirhaeghe⁴, Jean Dallongeville⁴, Anthony Kafatos⁵, Ascensión Marcos⁶, Dénes Molnar⁷, Yannis Manios⁸, Jonatan R Ruiz⁹, Idoia Labayen¹⁰, Kurt Widhalm¹¹, Christina Breidenassel¹², Marcela Gonzalez-Gróss¹³, Luis A Moreno²

Affiliations

¹ Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain. Electronic address: [email protected].
² GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain.
³ Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil.
⁴ INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France.
⁵ Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece.
⁶ Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain.
⁷ Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
⁸ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
⁹ Promoting Fitness and Health through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
¹⁰ Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
¹¹ Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria.
¹² Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
¹³ Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain.

PMID: 25129643
DOI: 10.1016/j.jpeds.2014.07.007

Abstract

We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Blood Pressure / genetics*
Blood Pressure Determination
Energy Metabolism
Exercise / physiology*
Female
Humans
Hypertension / etiology
Hypertension / genetics*
Life Style
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Genetic
Polymorphism, Single Nucleotide*
White People / genetics

Substances

NOS3 protein, human
Nitric Oxide Synthase Type III
MTHFR protein, human
Methylenetetrahydrofolate Reductase (NADPH2)