Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice

Lay Hoon Tang; Jie Hui Lim; Li Fang Kuah; Yuk Fai Lau

doi:10.1016/j.vaccine.2014.07.087

Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice

Vaccine. 2014 Sep 22;32(42):5375-8. doi: 10.1016/j.vaccine.2014.07.087. Epub 2014 Aug 15.

Authors

Lay Hoon Tang¹, Jie Hui Lim¹, Li Fang Kuah¹, Yuk Fai Lau²

Affiliations

¹ Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore.
² Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, 169857, Republic of Singapore. Electronic address: [email protected].

PMID: 25130540
DOI: 10.1016/j.vaccine.2014.07.087

Abstract

A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protected with no significant weight loss. The results have direct implications on how to overcome potential vaccine shortage and identify donors for immune sera for passive immunization.

Keywords: H7N9; Influenza; Vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Neutralizing / blood
Antibodies, Viral / blood
Cross Reactions
Influenza A Virus, H7N7 Subtype
Influenza A Virus, H7N9 Subtype*
Influenza Vaccines / immunology*
Mice, Inbred BALB C
Neutralization Tests
Orthomyxoviridae Infections / prevention & control*
Reassortant Viruses / immunology
Vaccines, Inactivated / immunology

Substances

Antibodies, Neutralizing
Antibodies, Viral
Influenza Vaccines
Vaccines, Inactivated