Abstract
A unique iron-catalyzed oxidative diamination of nitroalkene with 2-aminopyridine for the synthesis of 2-nitro-3-arylimidazo[1,2-a]pyridines with complete regioselectivity has been achieved under mild and aerobic reaction conditions. This is the first method for the synthesis of 2-nitroimidazo[1,2-a]pyridines. These scaffolds were also synthesized directly from styrenes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry
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Amination
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Aminopyridines / chemical synthesis*
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Aminopyridines / chemistry
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Catalysis
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Iron / chemistry*
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Molecular Structure
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Nitro Compounds / chemical synthesis*
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Nitro Compounds / chemistry
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Oxidation-Reduction
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Stereoisomerism
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Styrenes / chemistry
Substances
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Alkenes
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Aminopyridines
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Imidazoles
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Nitro Compounds
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Pyridines
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Styrenes
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Iron
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alpha-aminopyridine