The main symptom of multiple myeloma (MM) are pathological changes in bone. Imaging techniques are useful in determining the proper stage of the disease, follow-up after treatment and, as highlighted in recent times, in predicting prognosis and prediction. In the near future, radiographic examination of the whole body can be replaced by more sensitive techniques, such as low-dose computed tomography (CT) of the whole body. Magnetic resonance imaging (MRI) is a standard in the evaluation of bone marrow infiltration of the spine, allowing the prediction of the risk of vertebral fractures. Positron emission tomography (PET) coupled with CT (PET/CT) provides relevant information on the extent of lesions throughout the body, including soft tissues and is the best tool to distinguish active from inactive disease after treatment. Diagnostic imaging technique of PETIMR has the potential for precisely diagnosing in this condition. Prospective use of new imaging techniques in clinical practice in the near future will help to optimize the therapeutic management in individual cases of MM.