Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosylrhodamine probe

Chem Commun (Camb). 2014 Oct 11;50(79):11735-7. doi: 10.1039/c4cc04568h.

Abstract

This study depicts the 'click' construction of a water-soluble galactosyl rhodamine that can selectively probe mercury ions internalized by hepatoma cells over other cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asialoglycoprotein Receptor / genetics
  • Asialoglycoprotein Receptor / metabolism
  • Carcinoma, Hepatocellular / metabolism*
  • Click Chemistry
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / pharmacology*
  • Galactose / chemistry
  • Galactose / pharmacology*
  • HCT116 Cells
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / metabolism*
  • Mercury / metabolism*
  • RNA, Messenger / metabolism
  • Rhodamines / chemistry
  • Rhodamines / pharmacology*

Substances

  • Asialoglycoprotein Receptor
  • Fluorescent Dyes
  • RNA, Messenger
  • Rhodamines
  • Mercury
  • Galactose