Abstract
The prolonged continuous intraperitoneal infusion of cytoarabin was studied in 28 courses. Only 9 courses were completed for the full period of 3 weeks. No cytoarabin was detected in the plasma of patients on any of these courses. The combination of intraperitoneal administration of methotrexate and dipyridamole did not show a synergistic interaction of these 2 substances. However, the addition of dipyridamole to etoposide showed a clear synergy between these 2 substances studied on a human ovarian carcinoma cell line.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Dipyridamole / administration & dosage
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Dose-Response Relationship, Drug
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Drug Evaluation
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Drug Synergism
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Etoposide / administration & dosage
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Female
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Humans
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Infusion Pumps
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Infusions, Parenteral / instrumentation
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Long-Term Care
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Methotrexate / administration & dosage
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Ovarian Neoplasms / drug therapy
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Peritoneal Neoplasms / drug therapy*
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Tumor Cells, Cultured / drug effects
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Tumor Stem Cell Assay
Substances
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Antineoplastic Agents
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Dipyridamole
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Etoposide
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Methotrexate