Ataxia, ophthalmoplegia, and impairment of consciousness in a 19-month-old American boy

Semin Pediatr Neurol. 2014 Jun;21(2):139-43. doi: 10.1016/j.spen.2014.04.015. Epub 2014 Apr 15.

Abstract

A 19-month-old, white, Pennsylvanian boy, with an unremarkable medical history, presented to our hospital with a 3-week history of nonbloody, nonbilious emesis up to 5 times a day and nonbloody diarrhea. Ten days before admission, his gait became progressively unsteady, until he finally refused to walk. A day before admission, he found it difficult to move his eyes. The patient was hypoactive. History, physical and neurologic examination, blood and cerebrospinal (CSF) fluid studies, and neuroimaging studies ruled out the most frequent causes of acute ataxia. The etiology of bilateral, complete ophthalmoplegia was also taken into consideration. Magnetic resonance imaging (MRI) findings of bilateral thalami and mammillary bodies provided diagnostic clues. Additional history and specific tests established the final diagnosis and treatment plan. The patient improved to a normal neurologic state. This case provides important practical information about an unusual malnutrition cause of acute ataxia, particularly in young children of developing countries.

Publication types

  • Case Reports

MeSH terms

  • Ataxia / diagnosis
  • Ataxia / pathology
  • Ataxia / physiopathology*
  • Consciousness Disorders / diagnosis
  • Consciousness Disorders / pathology
  • Consciousness Disorders / physiopathology*
  • Diagnosis, Differential
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Ophthalmoplegia / diagnosis
  • Ophthalmoplegia / pathology
  • Ophthalmoplegia / physiopathology*
  • Thiamine / administration & dosage
  • Thiamine Deficiency / diagnosis*
  • Thiamine Deficiency / pathology
  • Thiamine Deficiency / physiopathology*
  • Thiamine Deficiency / therapy
  • United States

Substances

  • Thiamine