P68 RNA helicase as a molecular target for cancer therapy

Ting-Yu Dai; Liu Cao; Zi-Chen Yang; Ya-Shu Li; Li Tan; Xin-Ze Ran; Chun-Meng Shi

doi:10.1186/s13046-014-0064-y

P68 RNA helicase as a molecular target for cancer therapy

J Exp Clin Cancer Res. 2014 Aug 24;33(1):64. doi: 10.1186/s13046-014-0064-y.

Authors

Ting-Yu Dai¹, Liu Cao², Zi-Chen Yang³, Ya-Shu Li⁴, Li Tan⁵, Xin-Ze Ran⁶, Chun-Meng Shi⁷

Affiliations

¹ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
² Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
³ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
⁴ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
⁵ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
⁶ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].
⁷ Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. [email protected].

Abstract

The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and beta-catenin. More than that, post-translational modification of p68 including phosphorylation, acetylation, sumoylation, and ubiquitylation can regulate the coactivation effect. Furthermore, aberrant expression of p68 in cancers highlights that p68 plays an important role for tumorgenesis and development. In this review, we briefly introduce the function and modulation of p68 in cancer cells, and put forward envisagement about future study about p68.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
DEAD-box RNA Helicases / antagonists & inhibitors*
DEAD-box RNA Helicases / chemistry
DEAD-box RNA Helicases / metabolism
Drug Design*
Enzyme Inhibitors / therapeutic use*
Gene Expression Regulation, Neoplastic / drug effects
Humans
Models, Molecular
Molecular Targeted Therapy*
Neoplasms / drug therapy*
Neoplasms / enzymology
Neoplasms / genetics
Neoplasms / pathology
Protein Conformation
Signal Transduction / drug effects
Structure-Activity Relationship

Substances

Antineoplastic Agents
Enzyme Inhibitors
DEAD-box RNA Helicases