Biological activity, pH dependent redox behavior and UV-Vis spectroscopic studies of naphthalene derivatives

J Photochem Photobiol B. 2014 Nov:140:173-81. doi: 10.1016/j.jphotobiol.2014.07.010. Epub 2014 Jul 24.

Abstract

Two naphthalene derivatives, naphthalene-2,3-dicarboxylic acid (NDA) and 1,8-dimethoxynaphthalene (DMN) were screened for antioxidant and anti-diabetic activities. Biological antioxidant studies revealed NDA as more effective antioxidant as compared to DMN. Both compounds significantly increased the cholesterol level but showed varied biological activities as regards glucose and triglyceride concentrations. The cytotoxicity results evidenced DMN to significantly inhibit the cell proliferation in a dose dependent manner with IC₅₀ of 0.13 mM. Like the biological antioxidant studies, the electrochemical results also witnessed NDA as stronger antioxidant than DMN. The pH dependent spectrophotometric and electrochemical behavior was investigated in order to provide useful mechanistic insights about the biological role of the selected compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Blood Glucose / metabolism
  • Electrochemistry
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Hypoglycemic Agents / chemistry*
  • Hypoglycemic Agents / pharmacology*
  • Male
  • Naphthalenes / chemistry*
  • Naphthalenes / pharmacology*
  • Oxidation-Reduction
  • Rats
  • Rats, Sprague-Dawley
  • Spectrophotometry, Ultraviolet

Substances

  • Antioxidants
  • Blood Glucose
  • Hypoglycemic Agents
  • Naphthalenes
  • naphthalene