Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets

Mycopathologia. 2014 Oct;178(3-4):285-90. doi: 10.1007/s11046-014-9803-z. Epub 2014 Aug 24.

Abstract

We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical transmission of Candida albicans from the mother to the triplets and revealed a slight diversity among the strains isolated from the neonates.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Candida albicans / classification*
  • Candida albicans / genetics
  • Candida albicans / isolation & purification
  • Candidemia / congenital*
  • Candidemia / microbiology
  • Candidemia / transmission*
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • Fatal Outcome
  • Female
  • Genetic Variation*
  • Genotype
  • Humans
  • Infectious Disease Transmission, Vertical*
  • Multilocus Sequence Typing
  • Mycological Typing Techniques
  • Premature Birth*
  • Triplets*

Substances

  • DNA, Fungal