A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites

Chuang Li; Ping Chen; Yu Shao; Xu Zhou; Yuzhou Wu; Zhongqiang Yang; Zhibo Li; Tanja Weil; Dongsheng Liu

doi:10.1002/smll.201401906

A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites

Small. 2015 Mar;11(9-10):1138-43. doi: 10.1002/smll.201401906. Epub 2014 Aug 26.

Authors

Chuang Li¹, Ping Chen, Yu Shao, Xu Zhou, Yuzhou Wu, Zhongqiang Yang, Zhibo Li, Tanja Weil, Dongsheng Liu

Affiliation

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

PMID: 25155469
DOI: 10.1002/smll.201401906

Abstract

A polypeptide-DNA hydrogel is prepared by employing the "X"-shaped DNA assembling structure as crosslinker. The hydrogel can be modified with multifunctional components (here fluorescent molecules as a model) and possesses excellent self-healing and thixotropic properties, enabling the direct-writing of arbitrary 3D structures. This study provides a simple, universal strategy for the assembly of functionalized hydrogels.

Keywords: DNA hydrogels; multifunctional; polypeptides; self healing; thixotropic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Cell Culture Techniques
Chromatography, High Pressure Liquid
Cross-Linking Reagents / chemistry
DNA / chemistry*
DNA, Single-Stranded / chemistry
Electrophoresis, Agar Gel
Fluorescent Dyes / chemistry
Hydrogels* / chemistry
Nanotechnology / methods
Oligonucleotides / chemistry
Peptides / chemistry*
Rheology
Tissue Engineering
Tissue Scaffolds / chemistry

Substances

Cross-Linking Reagents
DNA, Single-Stranded
Fluorescent Dyes
Hydrogels
Oligonucleotides
Peptides
DNA